Just What Is Online Development? | Online Success Articles

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The term ?web development? has expanded and advanced a great deal in the last decade. It used to be that having an internet existence was a novelty, something to throw on a business card or in a commercial. Websites were reserved for the businesses with the means to spread them widely, or for individuals that didn?t care who observed what they posted.

Web development is noticeably different these days. The end objective is the same? a site on the Internet designed to market an organization, service or firm. These days you could also sell products and services, correspond directly with the business and do so much more. What is web development these days?

Web development has actually come to be a mixture of discipline and also art, just the same as marketing. To succeed online, one needs to understand exactly what to do as well as just what not to do so that a search engine picks them up. On top of that, a website has to be produced for the ultimate utility and usability. We?ve come a long way from the days of frames, embedded music and animated backgrounds. A web page is a major tool for serious enterprises.

Another major distinction is the procedure. Web composition is no longer about setting up a descriptive page and letting it sit. Sites have to be consistently updated, with material suitable for the business and their intentions. Going too long without an update loses visitors and also loses trust. Social media websites have a substantial influence in this too. A firm that ties their internet existence into sociable media is a lot more in touch with their readers and can benefit directly from that contact.

Once again, what is web development? It?s all relating to the online presence. Holding a presence on the internet is just as essential as having a physical storefront, and takes just as much work. Designing an internet site concerns style and substance, the balance amidst a fancy site and a site that can be utilized by all. All of this needs to be carefully planned and implemented by talented designers and online developers that know the markets and know exactly what they?re doing.

Thankfully, there are a lot of proficient designers out on the market, all set to create the perfect website for any type of business, local or otherwise. As complex as it is creating an internet site, there are individuals who make it their life?s work. Virtually every great website these days has a proficient developer behind it, and it shows. That?s web development.

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Popular Forum Traffic Planet Uncovers Negative SEO, the Dark ...

London, UK -- (SBWIRE) -- 05/31/2012 -- Millions of businesses who operate within the online space rely on one company for the clear majority of their traffic; Google. With what could almost be described as a monopoly on internet search, Google is unassailable within the market ? and they hold the lives of millions of businesses in the palm of their hands.

Recently, conversation across the web has turned to various algorithmic updates on the part of the search giant. Having their origin with the much-hyped ?Panda? update in February last year, the changes Google have recently made to their algorithm were ostensibly aimed at reducing the rank of so-called ?low-quality? sites while ensuring highly relevant sites of good quality were returned to the top of the rankings.

Due to a group of savvy users of popular internet marketing forum Traffic Planet, however, a dark side to the new changes has been revealed, and it?s turned the world of SEO on its head.

The idea of Negative SEO is relatively straightforward. Unlike traditional SEO in which the goal of the exercise is to improve the search rankings of site, Negative SEO is strikingly different. By targeting a competitor, it was theoretically possible for aggressive marketers to force websites down in search engine rankings. Well, it?s theory no more. Due to case studies conducted by Traffic Planet members recently, it?s been proven that Negative SEO is alive and well. It also may be that Google?s algorithmic changes are, in fact, the real culprit.

As an example of the results Traffic Planet members were able to achieve, one should look no further than a website owned by popular SEO industry figure Dan Thies. After a month of activity, a sustained Negative SEO campaign demonstrated some alarming results, with the rankings of three of his most prominent keywords significantly reduced. One keyword was confirmed to have dropped over a thousand spots.

Internet-reliant businesses are, of course, up in arms. While the way in which Google has cornered the search market over recent years has, for the most part, seemed benign, the issues surrounding a monopoly in this huge sector within the global economy are now finally coming to the fore. If the results demonstrated on the Traffic Planet forums begin to be widely replicated within the internet marketing industry, the whole sector may be in for a very rough ride indeed.

Terry Kyle, founder of Traffic Planet and a prominent figure within the SEO community doesn?t mince words on how ? or why ? it?s possible that Google?s own algorithm may be responsible for the advent of Negative SEO. ?Google is an advertising business, not a search business. Search just happens to be their delivery platform ? and it?s an effective one.? The SEO expert goes on to explain that, while seemingly unsavoury, the practice of Negative SEO might actually work to Google?s favour, something which would explain why the practice has been pointedly ignored by the search giant thusfar. While Google rankings remain fluid and unpredictable, it could be said that safer advertising investments would be, unsurprisingly, Google?s own Adwords paid advertisement platform. The idea that Google could be offering tacit approval for Negative SEO is alarming, to say the least.

As businesses rightly show concern for the implications of Negative SEO, the most troubling of which would involve a competitors marketing budget being redirected towards aggressive attempts to lower a business?s search ranking, questions continue to be asked about the role of Google in ensuring the viability of ethical internet marketing as well as their responsibility to safeguard the livelihood of the millions of legitimate, hardworking online businesses all over the globe. While the internet owes Traffic Planet a great deal of gratitude for uncovering this shocking development, only time will tell if the chilling potential of Negative SEO will be addressed sufficiently by Google to ease the minds of business owners everywhere.

About Traffic Planet
Traffic Planet is the Web's premier online venue for advanced tactical discussions about search engine optimization, monetization and conversions (converting visitors to a website into buyers and email subscribers). All Traffic Planet tactical discussions are completely free to read and participate in and all levels of internet marketing skill are welcome. For more information, visit: http://trafficplanet.com/

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Energy Saving and Home Improvement. |

It has been recently estimated that up to 30 Million businesses and homes will have been fitted with the latest ?Smart Meters? by the end of 2019, This estimate comes quickly on the heels of a recent declaration from Charles Hendry (UK Energy & Climate Change Minister) outlining that the benefit of the consumer is at the centre of the progamme.

The idea of having a smart meter installed is for consumers to be able to get accurate information on energy uses and stop bills being haphazardly estimated.

Recently, the UK?s Energy and Climate Change minister declared that in less than 3 years there will be a ?mass roll-out? of smart meters. In essence, this is all part of the governments? drive for the UK to achieve the treasured ?low carbon economy? status.

It?s clear then, that the folks at the top are starting to work on lowering the consumption of energy across the whole of the UK, and bit by bit, they are trying to pull us along with them towards taking energy savings measures seriously.

Already in the UK, there are clear indications that energy inefficiency in residential properties is being frowned upon, legislated against and in the some cases, such as with eligibility for the full rate of Feed in Tariff for Solar Panels, financially penalised.

(Source:http://www.decc.gov.uk/en/content/cms/news/pn12_010/pn12_010.aspx)

Building regulations and planning permissions in the UK are now intrinsically linked to the energy efficiency of the proposed home improvement. With discussions already going on at government level to impose even more planning permission restrictions ? in my opinion, these proposals could be interpreted as saying:??If the rest of your home is not energy efficient, we won?t give you permission to do this new work?.

How can I tell how energy efficient my home is?

The simple answer is to check your property?s Energy Performance Certificate (EPC). This is a report which every home in the UK should have. If you don?t have one already, it?s probably because you have been in the property since before the EPC came into being. Anyone who has recently bought, sold or rented a property in the UK should have had the property surveyed by an accredited Domestic Energy Assessor (DEA) and have been issued an EPC.

The EPC gives your property a rating from A to G (A is the best rating) and also sets out the ?best actions? you can take to improve the efficiency of the property and the potential improved rating after the work has been done. If you are the person buying or if you are person renting from a landlord, then it is the seller or the landlords? responsibility to sort out the EPC.

You can find an example of an energy efficiency report here:

www.communities.gov.uk/documents/planningandbuilding/pdf/2116821.pdf

What type of energy efficiency home improvements can I make?

If you are thinking of doing some home energy efficiency improvements there is quite a lot that can be done some quite ?cheap & cheerful?, some are more complex and require a higher initial financial investment.

In terms of the cost of this type of energy use improvement, there is soon to be some financial help from the UK government under the proposed ?green deal?.

10 energy efficient home improvements you can make to your home.

• Install a Smart meter
• Energy saving lighting systems
• Draught proofing for existing Windows & Doors
• Insulate water tanks & Pipes
• Loft insulation / Floor Insulation
• Cavity Wall insulation / Solid Wall Insulation
• Modern Water Boilers with effective thermostats and controls
• Secondary Double Glazing / Replacement Double glazed windows / Triple Glazed Windows
• Composite Doors / Upvc Doors
• Heat Pumps (Air source Heat Pumps / Ground source Heat pumps)

There are literally dozens of other things which could be added to this list.

It?s understandable to look at the list and think ?it?s going to cost me a fortune to be green?, but think about how much energy costs are rising ?

British Gas announced a rise in gas and electricity prices of up to18% in 2011

This kind of increase can double the size of your bills every few years, and if you don?t start to act now, you may find yourself being ?held to ransom? by the energy companies in the not too distant future.

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How to prepare for bus trips

Planning for bus trips is a very careful exercise that one should not take lightly. The trips maybe a fun trip with family and friends or an educational trip with school friends and teachers or even a business trip to ink a deal; in all circumstances, it would be advisable to prepare well beforehand and avoid last minute mess. Just as important is preparation, so is observing certain etiquettes while on a bust trip. This article deals with these subjects.

Planning

A reputation of safety is what you should be looking for while hiring a company for bus trips. There are more accidents today than there were probably two years ago so it is important that you have a careful driver at the wheel. You can measure reputation by the number of references that you receive from peers.

Bus services usually run on a fixed schedule and provide the same to passengers so that they can prepare right.

Traveling light

The space on a bus is usually limited and too much of luggage can cramp up your experience. Take with you only essentials such as medicines, cash, clothes and a few are reading materials. Two luggage bags would be ideal and these can be kept at the cargo bay of the bus. For immediate needs, you can have a shoulder bag that you can bring to your seat. Bus companies often specify the luggage criteria that can be brought on their trips. Bus trips would be enjoyable if you did not have any concern over the security of your luggage and one way of doing this would be by being as less encumbered as possible.

Booking in advance

Like any other mode of travel, book in advance to avoid the last minute rush for tickets. Buses are the last resort if travelers miss out on train and airplane tickets or if destinations are closer by bus. A reliable calendar can give you the local holidays if you are foreign to the area. Weekday and night traveling are usually less expensive.

Prop

One of the great things about bus trips is that you get to see the country side. This however can get boring since the brain cannot keep processing ?wow? all the time. Eventually, a chicken crossing the road is just another chicken crossing a road. Divert your attention for a while by reading a book or listening to music. Bring a friend on the trip or get friendly with the neighbor. Talking to somebody has always been interesting to humans.

At stopovers

Ever had that trip where one passenger stays in the toilet for too long? Going ?missing? is something that gives great inconvenience to the rest of the passengers. It is therefore advisable to be seated within the bus as much as possible. When the bus pulls over for refreshments and fuel, you could go out to stretch as a bus trip can be tiring. Let the driver know where you will be so that they can find you when they decide to move.

Bus trips are a wonderful way to see the country side. With modern buses, you can expect your trip to be comfortable and on time for most journeys.

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NuForce Cube Speaker: Jack of Many Trades, Master of None [Lightning Review]

Fitting quality audio components into slim laptops and tiny smartphones takes nothing short of a herculean effort, and as a result, is something often overlooked by hardware manufacturers. Realizing this, NuForce has spent the last year developing a line of products meant to enhance the tech we use daily, geared towards the not-quite-an-audiophile consumer who still wants good audio at a reasonable price. Its latest entry is the NuForce Cube, a combination speaker/headphone amp/USB DAC wrapped up in a tiny package for an audio boost on the go. But is it worth the extra weight? More »

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Improving the local financial system basic financial trouble relief ...

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Along with the development of the reform of rural taxes and deepening, the cancellation of the agricultural tax, tax conformity between urban and rural areas, already is the trend of The Times. However, the reform of rural taxes to reduce the burden on farmers at the same time, inevitably led to the financial resources to aabbcc498373791 reduce the county and township governments, especially as the main financial income tax of the cancelled, will further increase the difficulty of the finance. I think that the financial system is not perfect basic financial difficulties caused by the important reason, to successfully promote the reform of rural taxes and fundamentally relieve the farmers? burden, to ensure smooth running the government, we must speed up the local finance system construction, alleviate county and township government financial trouble.
First, the current financial system with perfect is the root of the trouble caused the financial resources

cheap ray ban sunglasses 1994 years since the tax, the central and between the provinces of fiscal system has been improved, the contradiction of financial allocation gradually transferred to save the following local governments at all levels, especially the financial difficulties and financial resources county and township governments run dilemma gradually revealed, since it is caused by the farmers? burden aggravation of the important reason, and the reform of rural taxes biggest problem. The financial difficulties caused by the financial system reason mainly have the following:
1. The financial governance is too big, too small property, conform with property does not adapt, is causing the financial mess up basic reason
ray ban sunglasses In our current system of first division central and local income, but government at all levels of the division between governance, management system is still more chaos, the superior government formulated with system right thing will be down, but often not financial guarantee, caused by the governments at lower levels, especially the government assumes the consistency of county and township governments overweight, property and consistency of asymmetry, often have powers and no property, financial operation difficulty, thus have to to farmers and town enterprise hand and become the important factor of farmers? burden.

So, as long as the property and consistency of unity, do not have much money, do much, how many people have, grassroots financial operation difficult situation can change, plus associated with the tax revenues of channel of the budget, and they?ll seek through the institutions to expand financial income ?adoptee? and ?construction?, the farmers? burden is hard to avoid can ?pressed the hoist up the gourd ladle,? no cure.

2. Lack of duty of local governments at various levels shall, according to the subordinate relations division income, lead to financial resources distribution layer upon layer ?catch centralization?, the financial gain financial further reduce
On the one hand, in our tax system structure, suitable for ZhongYangShui as the tax is numerous, suitable for the categories of taxes that local taxes as less, local taxes system construction the serious lag. At all levels for finance all failed to form the main body of have the features of taxes. From provincial government to local finance, and then to county finance, taxes are a very similar, business tax, value added tax and enterprise income tax and other major categories of taxes at the corresponding level to the importance of financial order also completely the same. At all levels for finance common to share the same, a limited number of kind of tax, income potential is limited, go against the government at all levels according to the local tax sources characteristic, forms the different financial foundation ray ban sunglasses discount .

On the other hand, the superior financial shares duty in the distribution of income in ?catch centralization?, leading to further reduce the financial resources. Governments at all levels with financial system right formulated, in the main categories of taxes on the distribution of some by administrative subordinate relations points tax, according to some industry points tax, each grabbing big, big, big tax sources of taxes will catch hand, to the financial almost no tax can be divided, miscellaneous and income tax in small scale, the financial income sources caused instability. To agricultural tax for duty township financial, is undoubtedly the most weak financial resources the government at the next higher level. And after abolition, if do not take the corresponding reform measures, county and township government fiscal regime can not run normally.

3. Financial transfer payment money does not reach the designated position, can?t fundamentally solve county and township government financial difficulties.
In theory, transfer payment main goal is public social service equal access. But in China the transfer payment funds primarily used to ensure that the government spending and normal institutions maintenance operation, also do not have the resources to ensure that for some specific social and public services, such as education, public health, etc. And our country transfer payment funds to tax return, special allowance give priority to, its itself does not have prompted regional financial difference of narrow effect, lead to transfer payment system resources enough to equal access. In addition, although transfer payment in relieves financial trouble county and township governments, many county use province transfer payment increases the nine-year compulsory education public services such as investment, but each provincial financial transfer payment subsidies can only make up for general county and township governments financial revenue and expenditure of the gap 60-70%, and some relative to county and township government financial difficulties to see, these transfer payment funds obviously can?t fundamentally solve the financial difficulties.
Through the above analysis we can see, don?t adjust the financial system, to not take too much of county and township governments adjustment consistency, you cannot solve the problem of the dilemma facing financial resources.

Second, improving the local financial system, to alleviate the financial trouble Suggestions
1. To establish a scientific and standardization of the government at all levels, the division of the consistency between spending pattern, appropriately reduced spending powers rural county and township governments
?Property and consistency of relative says,? is to guarantee the smooth operation of the government of the foundation. But now the property and the fiscal powers not unified, powers greater than property, leave plenty of hard gap, so must adjust county, township financial expenditure limits.
Because our country for a long time ?rural support city? of ?culture? economic development pattern, rural areas behind the development of long-term, therefore, rural basic education than in rural areas things, and not the farmers of the masses themselves things, but rather with the whole country, the whole nation is closely related to the development. So should increase the central, provincial finance in the basic education, public health powers of duty, to further reduce the government in the basic education county and township governments, public health undertake the responsibility of governance, and appropriately reduced pressure county and township governments of fiscal expenditure, which will help to alleviate the financial difficulties in rural areas.
2. Their main body at all levels for finance construction of taxes, financial resources allocation to grassroots financial tilt
First of all, according to the nature of the income tax division belongs, and establish the local governments at all levels of the respective duty, completely change the distribution of resources in ?layer upon layer concentration?, financial resources allocation to grassroots financial tilt. At the same time, gives provincial local government necessary tax legislation, improve its income organizational ability.
Second, is to strengthen the business tax, property taxes and other local taxes system construction,

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Companies risk harm from cash glut: survey

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Precision ERP Bring In SAP Change Management Analyst In ...

Job Title : SAP Change Management Analyst
Company : Precision ERP
City : Montr?al
State : Quebec
Country : CA
Location : Montr?al, QC
Date : 2012-05-28 16:08:43
latitude : 45.508244
longitude : -73.58242
Status Active
Job key fbd497ec9ebda982

Introduced at May 28, 2012. Today is Precision ERP for the date put to work SAP Change Management Analyst. The profession situated inside city Montr?al, QC middle of nowhere of Quebec QC.

Also the status of the job is Active. So besure to look at the job explanation below and continue hit the APPLY THE JOB button to go forward further.

The summary of job description of SAP Change Management Analyst :

SAP Change Management Analyst Job explanation provided by Precision ERP. If you can quick apply this job you only click the Apply the job button at the bottom of this information.

We are seeking a Change Management professional for our Montreal area client This is a contract position for up to 8 months. Requirements: - Strong communication skills in both English and French - Expereince working on SAP business transformation - Excellent project management skills - Excellent organisational change management skills - Manufacturing and production experience...

MAP OF JOB LOCATION :

If you can view the location of Precision ERP company you only click View The Map button. Zoom in to acquire a closer glance in the where about of job and execute a Street View, to provide oneself a lil small sight from the where about of profession prior to going there.

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The unusual confessor who broke the Etan Patz cold case

Killing Etan Patz in 1979 may have been the only time alleged killer Pedro Hernandez hurt someone. While he avoided detection for 33 years, the secret took enough of a toll that Hernandez broke down in tears as he confessed, appearing remorseful and ?relieved.?

By Patrik Jonsson,?Staff writer / May 26, 2012

Pedro Hernandez is arraigned in Manhattan Criminal Court via video link seen here in this courtroom sketch in New York Friday. Hernandez has confessed to killing Etan Patz.

Shirley Shepherd/Reuters

Enlarge

After New York police dug into a SoHo basement in April searching for the remains of Etan Patz, a 6-year-old New Yorker who disappeared on May 25, 1979, Pedro Hernandez did something very unusual, family members told the press: He called his sister in New York, to talk about the case.

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Working off a tip from an unnamed source, New York police on Friday arrested and arraigned Mr. Hernandez. It was the 33rd anniversary of the day when the tow-headed Etan, lugging a backpack painted with cartoon elephants, disappeared as he walked alone to school for the first time. The subsequent search for Etan sparked national ?stranger-danger? fears and turned May 25 into the federally-recognized National Missing Children?s Day.

The man who had allegedly kept a sinister secret for 33 years broke down during a 3 ? hour interrogation on Wednesday. He appeared both remorseful and ?relieved,? New York detectives said.

RECOMMENDED: How one man stopped a child abduction, and six other heroic acts

According to police, Hernandez, then an 18-year-old stockboy at a SoHo bodega, said he lured Etan into the basement with a soda, then strangled him and put the body into a plastic bag, which was then presumably taken to a city landfill. Hernandez told police that he realized Etan was ?the one? after feeling an ?urge to kill.?

While little is known about Hernandez, the story given so far by police is peculiar, experts say, for several reasons, including the apparent lack of sexual assault motive and the fact that Hernandez, described by some as shy and standoffish, appears to have retreated from the act into a quiet middle-class existence in New Jersey, perhaps never hurting anyone again.

But whether as a precursor of the crime or a result, Hernandez, a disabled construction worker, reportedly has wrestled with psychological problems for years. On Friday, as Hernandez remained on suicide watch at Bellevue Hospital, his attorney, Harvey Fishbein, said Hernandez had a ?long psychiatric history,? including hallucinations, which a New York judge took into consideration, ordering a psychiatric evaluation to see whether he?s fit to stand trial.

Hernandez?s call to his sister and his ?relief? at unburdening his story hints at a criminal case that strays beyond the standard profile of a killer. For one thing, Hernandez had talked about doing ?a bad thing? as far back as 1981, though no one ever took him seriously enough to report that.

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Marine reserves boost fish: Australian study

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Inherited DNA change explains overactive leukemia gene

Public release date: 25-May-2012
[ | E-mail | Share ]

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

• An overactive BAALC gene in acute leukemia cells identifies patients whose disease is likely to respond poorly to standard therapy.
• This study discovered why the gene is often overactive.
• The findings may provide a prognostic marker that can help guide therapy in these patients.

COLUMBUS, Ohio A small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.

The study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) focused on a gene called BAALC. This gene is often overactive, or overexpressed, in people with acute myeloid or acute lymphoblastic leukemia, and it indicates that the disease is likely to respond poorly to standard therapy.

This study discovered that BAALC overexpression is caused by a small change called a single nucleotide polymorphism, or SNP (pronounced "snip") in the gene's DNA. The SNP alters the gene's "On" switch, allowing a different molecule to keep it "running" when it shouldn't.

"We want to emphasize," says principal investigator Dr. Albert de la Chapelle, professor of medicine, the Leonard J. Immke Jr. and Charlotte L. Immke Chair in Cancer Research, and co-leader of the Molecular Biology and Cancer Genetics Program, "that this SNP does not raise an individual's risk of developing leukemia, but it does predispose to overexpression of the BAALC gene, which is associated with leukemia development and poor response to treatment."

The findings, published recently in the Proceedings of the National Academy of Sciences, suggest that this SNP could be a useful marker of prognosis and for guiding therapy in acute leukemia patients.

Specifically, the DNA change caused by the SNP creates a binding site for an activating molecule called RUNX1, which is also involved in the formation of normal and malignant blood cells. The researchers showed that patients with high levels of RUNX1 protein also had high levels of BAALC gene expression, while those with low RUNX1 protein had low BAALC gene expression.

For this study, de la Chapelle and his colleagues used DNA sequencing to examine the genomic region of BAALC in 253 patients with cytogentically normal AML (CN-AML) treated in Cancer and Leukemia Group B clinical trials. The analysis revealed nine SNPs of interest, but the researchers focused only on one called rs62527607[T] which creates a RUNX1 binding site in the BAALC promoter region.

The researchers validated the findings in 105 CN-AML patients enrolled in the German-Austrian AML Study Group trials for adult patients. The validation group findings supported the association of high BAALC expression with the SNP, and high RUNX1 expression with high BAALC expression.

"We doubt that this SNP is entirely responsible for BAALC overexpression, but we do believe it is a major contributor to the overactivity," de la Chapelle says.

###

Other researchers involved in this study were Ann-Kathrin Eisfeld, Guido Marcucci, Sandya Liyanarachchi, Sebastian Schwind, Katie Maharry, Benjamin Leffel, Michael D. Radmacher, Clara D. Bloomfield and Stephan M. Tanner of Ohio State University; and Konstanze Dhner and Hartmut Dhner of University of Ulm.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 25-May-2012
[ | E-mail | Share ]

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

• An overactive BAALC gene in acute leukemia cells identifies patients whose disease is likely to respond poorly to standard therapy.
• This study discovered why the gene is often overactive.
• The findings may provide a prognostic marker that can help guide therapy in these patients.

COLUMBUS, Ohio A small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.

The study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) focused on a gene called BAALC. This gene is often overactive, or overexpressed, in people with acute myeloid or acute lymphoblastic leukemia, and it indicates that the disease is likely to respond poorly to standard therapy.

This study discovered that BAALC overexpression is caused by a small change called a single nucleotide polymorphism, or SNP (pronounced "snip") in the gene's DNA. The SNP alters the gene's "On" switch, allowing a different molecule to keep it "running" when it shouldn't.

"We want to emphasize," says principal investigator Dr. Albert de la Chapelle, professor of medicine, the Leonard J. Immke Jr. and Charlotte L. Immke Chair in Cancer Research, and co-leader of the Molecular Biology and Cancer Genetics Program, "that this SNP does not raise an individual's risk of developing leukemia, but it does predispose to overexpression of the BAALC gene, which is associated with leukemia development and poor response to treatment."

The findings, published recently in the Proceedings of the National Academy of Sciences, suggest that this SNP could be a useful marker of prognosis and for guiding therapy in acute leukemia patients.

Specifically, the DNA change caused by the SNP creates a binding site for an activating molecule called RUNX1, which is also involved in the formation of normal and malignant blood cells. The researchers showed that patients with high levels of RUNX1 protein also had high levels of BAALC gene expression, while those with low RUNX1 protein had low BAALC gene expression.

For this study, de la Chapelle and his colleagues used DNA sequencing to examine the genomic region of BAALC in 253 patients with cytogentically normal AML (CN-AML) treated in Cancer and Leukemia Group B clinical trials. The analysis revealed nine SNPs of interest, but the researchers focused only on one called rs62527607[T] which creates a RUNX1 binding site in the BAALC promoter region.

The researchers validated the findings in 105 CN-AML patients enrolled in the German-Austrian AML Study Group trials for adult patients. The validation group findings supported the association of high BAALC expression with the SNP, and high RUNX1 expression with high BAALC expression.

"We doubt that this SNP is entirely responsible for BAALC overexpression, but we do believe it is a major contributor to the overactivity," de la Chapelle says.

###

Other researchers involved in this study were Ann-Kathrin Eisfeld, Guido Marcucci, Sandya Liyanarachchi, Sebastian Schwind, Katie Maharry, Benjamin Leffel, Michael D. Radmacher, Clara D. Bloomfield and Stephan M. Tanner of Ohio State University; and Konstanze Dhner and Hartmut Dhner of University of Ulm.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Blizzard fixing, updating bedeviled 'Diablo 3'

13 hrs.

Winda Benedetti

The launch of the decade-long-awaited "Diablo 3" has been bedeviled by a variety of issues, but the people behind the action role-playing game?say they have been busy fixing it?and will continue to make more fixes in the coming weeks.

With gamers complaining of being unable to access overloaded servers, of?achievements gone missing and of?gold stolen from hacked accounts, Blizzard has posted a lengthy message to players on its Battle.net forums?explaining that?it has been "working around the clock to address issues as quickly and efficiently as possible."?

Since the game's launch, we?ve applied a number of hotfixes?to address gameplay issues, made tweaks to improve our service stability and performed occasional server maintenance when necessary to ensure that in the long term, players have the best gameplay experience possible.

The message goes on to say that more server maintenance is still required and that Blizzard will be updating the game with a patch?"sometime next week" to address additional issues and bugs.

While Blizzard says it is still trying to figure out how to address the issue of achievements that went missing as gamers played?during the first days after launch, it doesn't sound like there's much to be done about the hacked accounts.

Despite some players speculating otherwise,?Blizzard insists that its servers have not been compromised and says that the number of players reporting hacked accounts is "extremely small." The company goes on to explain:

?In all of the individual Diablo III-related compromise cases we've investigated, none have occurred after a physical Battle.net Authenticator or Battle.net Mobile Authenticator app was attached to the player's account, and we have yet to find any situation where a Diablo III player's account was accessed outside of "traditional" compromise methods (i.e. someone logging using an account's login email and password) ...?

The best defense against account theft still includes smart password management (e.g. using a unique password for every site/service and keeping your password to yourself) and scanning for malware and viruses regularly, as well as following additional preventative steps found here.?

And in a final bit of news, Blizzard said that it has pushed back the launch of its?real-money auction house?(a place gamers will be able to use real money to to buy and sell virtual "Diablo 3" items) indefinitely.?

All of the troubles aside, "Diablo 3" is still?selling at a record-breaking pace. And the game continues to rake in high marks from reviewers. Here's what our own In-Game editor Todd Kenreck thought about it:

Winda Benedetti writes about games for msnbc.com. You can follow her tweets about games and other things here on Twitter or join her in the stream here on Google+. And for more video game news and reviews be sure to check out the In-Game Facebook page right here.

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Daily Caller giving away guns to readers through Election Day

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The way to elements Air Jordan Shoes with the Dominate Your ...

Fantasy soccer has become incredibly well-liked for many years as well as the Internet has elevated the popularity of fantasy sports Air Jordan in general to all time highs. One of the quickest growing fantasy sports is fantasy racing. The NASCAR Nextel Cup Series has exploded in recognition over the previous two decades promoting out all race activities and grabbing massive chunks of the Tv rankings. And that, in return, has improved the reputation of fantasy racing leagues.

You can find a broad selection of fantasy racing leagues to select from. Just like football, you are able to locate a neighborhood workplace pool exactly where you choose a driver or two every week to much more superior leagues that include multi-million dollar income caps and point methods. Some fantasy racing leagues are free of charge and other individuals charge a charge to take part. Contestants fight it out for bragging rights to a large number of dollars in cash and prizes.

Some take into account fantasy sports video games of likelihood but should you ask individuals that take part and get and finish close to the leading of their league(s) regularly, you?ll learn that fantasy sports are Games of Ability. You will need to research and stay up to date on all elements Air Jordan Shoes of the sport your fantasy league is depending on.

For fantasy racing leagues based on the NASCAR Nextel Cup Collection, you?ll need to study and chart how every single driver and his team perform at each track. NASCAR can be a group activity, a driver on your own can not get a race. If a driver changed teams during the off time, this might effect his efficiency. You will find 36 races on 23 diverse race tracks and over 50 motorists to choose from so your notes can get quite considerable.

Wallbanger Fantasy Racing offers a beneficial cheat sheet that you could individually chart drivers with. I suggest you print one particular and then make copies or you?ll be able to come up together with your personal method. If you?d like to dominate your league, you will need 23 pages (1 page for every track) for every driver you chart. You?ll also require a folder or binder to remain arranged.

You may be asking where do I commence! Here are several of the items that could factor in to which driver you choose at a specific race monitor:

Some Driver Aspects you need to keep records of include:
? How does this driver perform on brief tracks like Martinsville and Loudon
? How does this driver perform on flat ovals like Indy and Phoenix
? How does this driver perform on tremendous speedways such as Atlanta and Charlotte
? How does this driver performance on restrictor plate tracks (Daytona and Talladega)
? How does this driver carry out on a Road Course
? Does this driver have current Air Jordan several wins in a particular track
? Has the driver at any time raced at this track (Busch or Nextel Cup Series)
? Did the driver participate in Saturday?s race
? What?s the drivers average complete at this monitor
? What?s the motorists common end this time
? Does your driver have teammates How numerous Do they operate well collectively
? How well do the Driver and Crew Chief communicate
? How well does the Pit Crew carry out
? Will be the driver content together with his group
? Does this driver get very good gasoline mileage
? Does this driver sometimes make a mental error
? Does this driver typically strike some thing or get caught up in a wreck
? May be the driver intense
? Exactly where is your driver within the standings Close to a bubble spot

Some Race Day Variables contain:
? The drivers starting position
? The motorists location on Pit Road
? The drivers wellness status (sick or injured)
? Pleased Hour pace
? Pleased Hour or Air Jordan Retro Apply crash
? Day or Evening Race
? Pre race motor adjust

Some Track Variables contain:
? Surface area (Concrete or Asphalt)
? Banking (Flat, Common, Large Banked)
? Monitor Configuration: Oval, Street Course, Other
? Restrictor Plate Required
? Features a specific make of vehicle dominated this track
? Is gas mileage generally a factor here

Be sure to bear in mind that this really is racing. ?Rubbing is racing? and accidents WILL occur. Your driver could get collected in ?The Huge One? or may just blow a tire going into turn 3, that will happen but not as usually to those that study make smart options on race day.

The bottom line is that in case you take notes and research the game and its participants, you will finish a lot more regularly close to the top rated of the fantasy league standings week right after week. This may eventually land you a championship and an opportunity at successful some huge and often Air Jordan Retro lucrative prizes.

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Finding quotes for auto insurance on a new car | Auto and vehicle ...

Getting auto insurance quotes for a new car

So you?ve bought yourself a new car? Congratulations! That?s certainly a purchase that matters a lot to most car owners. Whether it?s your very first car or just another vehicle to add to your garage, buying a new car is always exciting. Each car certainly feels different on the road and you will always try to find the model that will make you feel comfortable both as a driver and as a passenger. But with a new car comes new responsibility, which always takes the form of insurance. And it?s this small bit of responsibility that can sometimes spoil all the fun about buying a new car since it can be really expensive. So let?s try to learn how to optimize insurance costs and not spoil the excitement of owning a new vehicle.

How you financed you purchase is the first thing and this really does matter. The most common option in our country is using auto loans since you can always get good rates and buy a car that you otherwise would have to save a lot of money for. But there?s a downside to using auto loans from the insurance perspective since you will be obliged to purchase additional types of coverage with your policy in order to get the loan. Most lending companies require collision and comprehensive coverage to be purchased with the insurance policy and that can considerably increase auto insurance quotes for your car. So make sure to consider this effect when financing your car through a loan. If you buy a car like this as it is your only option it is worth avoiding some of the more common mistakes people make.

First of all, don?t get the policy offer at the dealer?s office or by the lending company. They usually have exclusive contracts with specific companies and offer higher rates than you would get from a third party provider. You?re obliged to purchase additional coverage but they can?t make you buy it from a particular insurer. So when you get your loan take the time to get auto insurance quotes from as many companies as possible in order to get the most competitive offer possible. You will be surprised to see that you can actually find affordable policies even with collision and comprehensive coverage included. That?s the whole purpose of comparison shopping.

There are two main options to look at if you want to finance your car with your own money. First, you can get the most stripped down policy carrying only third party liability that will automatically offer cheaper auto insurance quotes right from the start. Of course, this means that the situations when your policy will apply will be quite limited. But instead you can save a lot of money on auto insurance. Yet, assuming that you can afford to buy a car without using credits, loans or any other forms of financing it?s logic that you actually have enough money to buy decent coverage for your auto as well. And you would certainly like to buy more coverage options in order to protect your car adequately. After all, things like comprehensive coverage or uninsured motorist coverage really come in handy in a range of situations where a basic policy would simply make you pay out of own pocket. Once you have celebrated buying your new vehicle you should definitely think about this.

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The People Bank Doing Business With Human Resources ...

Job Title : Human Resources Generalist - Toronto, ON
Company : The People Bank
City : Toronto
State : Ontario
Country : CA
Location : Toronto, ON
Date : 2012-05-23 13:43:37
latitude : 43.697803
longitude : -79.41209
Status Active
Job key a25b5cf1d1b5e81a

Declared at May 23, 2012. Is actually The People Bank at the moment employing Human Resources Generalist - Toronto, ON. The position placed inside region Toronto, ON range of Ontario ON.

And thus the condition of the job is Active. So besure to look at the job criteria below and go ahead hit the APPLY THE JOB button to commence further.

The summary of job description of Human Resources Generalist - Toronto, ON :

Human Resources Generalist - Toronto, ON Job criteria provided by The People Bank. If you can quick apply this job you only click the Apply the job button at the bottom of this information.

Other Area(s); The People Bank - Mississauga is currently looking for a Human Resources Generalist for our client in the manufacturing industry located in Toronto. This is a full-time, permanent position. In this role you will have full responsibility for all corporate HR functions for our client's unionized operations. This includes recruitment, selection, regulatory compliance, employee...

MAP OF JOB LOCATION :

If you can view the location of The People Bank company you only click View The Map button. Zoom in to acquire a closer glance in the where about of job and execute a Street View, to provide oneself a lil small sight from the where about of position prior to going there.

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The way to Nike Shox Develop A Home-Based Business ...

Constructing a house Nike Shox business has innumerable advantages for all those who can not do a regular nine-to-five occupation for a variety of personal or expert factors. 1 can operate and also look after his or her family members in the very same time, although constructing an enterprise which can be operated from home.

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This really is one of the most promising home-based businesses. This is operated and offered on the Globe Wide Web. Getting to be an associate with a company group can be a lucrative undertaking, as it practically wants no begin up money. But those that are thinking about this kind of company must have a clear expertise regarding computer systems and site constructing. A much better internet site attracts far more visitors which consequently generates fairly a good sale.

- #2 Free function at Nike Shox house selection ? Promoting items on the web:

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Marvel Comics Plans Its First Ever Gay Wedding Plot in 'Astonishing ...

May 23, 2012 07:12:14 GMT
The New York-based publisher will host the same-sex wedding between Northstar and his long-time boyfriend Kyle Jinadu in 'Astonishing X-Men' No. 51 to be released this summer.

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After scoring multiple records through its film, "", Marvel continues to make another groundbreaking creation through their comic division. The New York-based publisher announced on Wednesday, May 22 that it will host a same-sex wedding for its first ever openly gay superhero Northstar and his long-time boyfriend.

Northstar, whose human persona is known as Jean-Paul Beaubier, is set to tie the knot with his beau Kyle Jinadu this summer. The story will be told in "Astonishing X-Men" No. 51, which is due to be released in the United States on June 20.

"Astonishing X-Men" writer Marjorie Liu said of Beaubier and Jinadu's relationship, "The story of Northstar and Kyle is universal, and at the core of everything I write: a powerful love between two people who have to fight for it against all odds."

The writer added, "This is the quintessential Marvel story, one that blends the modern world with the fantasy of superheroes in order to tell an exciting story that begins with a wedding and continues in ways you can't imagine."

Marvel Comics editor-in-chief Axel Alonso added, as quoted by The Rolling Stones, "When gay marriage became legal in New York State, it raised obvious questions since most of our heroes reside in New York State. Northstar is the first openly gay character in comics and he's been in a longterm relationship with his partner Kyle so the big question was - how would this change his relationship?"

Northstar first revealed he was gay in the pages of "Alpha Flight" No. 106 released back in 1992. Their upcoming wedding will mark the first same-sex marriage happens in the Marvel Universe. Alonso added in another statement, "The Marvel Universe has always reflected the world outside your window, so we strive to make sure our characters, relationships and stories are grounded in that reality."

? AceShowbiz.com

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